The Review
Perricone MD Cold Plasma Plus+ Advanced Serum Concentrate Review: One Jar, Nine Promises
A full review of the Perricone MD Cold Plasma Plus+ Advanced Serum Concentrate: the copper tripeptide and vitamin C ester formula, the jar reality, owner sentiment, and who should buy a specialist instead.

How this review was made: from the manufacturer's published formula and specifications, the live Amazon listing, and recurring themes in owner commentary. Eclat Press does not claim hands-on testing it has not done, and publishes no scores.
The formula on paper
Read the published ingredient list and the jar is more interesting than its marketing. Copper Tripeptide-1 is the headline, but Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 stand behind it, which makes this a peptide concentrate first and a multitasker second. Vitamin C Ester brings the brightening system, DMAE the firmness signature, and omegas 3, 6 and 9 with sodium hyaluronate handle the comfort side. Glycolic acid sits in the formula too, a quiet exfoliating input worth counting if the rest of your routine is acid heavy.
Texture and the jar question
Despite the serum name, this is a cream textured concentrate, rich enough that dry skin owners use it as a light moisturizer and oily skin owners find it substantial in summer. The liquid crystal delivery system the brand describes is its explanation for how so much fits in one texture. The jar itself is the recurring friction: prestige pricing, an open top, and a formula owners would rather meet through a pump. Clean hands or a spatula are the practical answer, and the care guide in this hub returns to it.
What owners keep saying, both ways
Praise clusters on convenience and on breadth: routines simplified, skin looking more even in tone and smoother in texture together. The complaints are equally patterned: the jar, a noticeable scent on application, and a diffuse verdict problem, owners unsure which of the nine promises actually arrived. That diffusion is worth trusting as information. It is what a foundation layer feels like from the inside: everything a little better, nothing dramatically changed, which is either exactly what you wanted or a disappointment, depending on the brief you brought to it.
Concentrate or specialist: the in-house rivalry
This hub contains three products that compete with the concentrate's individual promises: the CCC+ complex out-brightens it, the Growth Factor serum out-firms it on paper, and the Deep Crease Serum out-targets it. The concentrate's defence is arithmetic: it costs one step where the specialists cost three, and it layers under any of them when a single concern graduates. Start here, then add specialists only where a concern survives a full jar of the foundation.
The Cold Plasma Plus+ Concentrate is the most Perricone product imaginable, for better and for the one honest worse.
From the verdict
In Owners' Hands
Recurring themes, in aggregate and without numbers we cannot stand behind.
What owners praise
- The all in one convenience, with owners describing simpler routines after switching to this jar
- Skin looking more even in tone and smoother in texture at the same time
- The rich but not greasy finish on dry and mature skin
What owners question
- The jar format divides owners who prefer pumps for hygiene and dosing
- With nine targets claimed, owners find it hard to say which benefit arrived first
- The scent of the concentrate is noticed on application by some
Consider Instead
Perricone MD High Potency Growth Factor Firming & Lifting Serum 2 fl oz
When the look of firmness is the single dominant concern, the polyamine and encapsulated retinol serum pursues it harder than the concentrate can

Perricone MD Vitamin C Ester CCC+ Ferulic Brightening Complex 20% 2 fl oz
When brightness is the project, three forms of vitamin C at 20 percent with ferulic acid is the dedicated tool
Questions, Answered
Is the Cold Plasma concentrate a serum or a moisturizer?
It sits between the two, by design: a serum concentrate with a cream texture. Dry and mature skin owners often use it as the last step in summer; most routines place it after cleansing and before a moisturizer, as this hub's routine guide sets out. Judge it by where it sits in your routine, not by the word on the jar.
How long does the 1 fl oz jar last?
Used on face and neck morning and evening as directed, owners describe a jar measured in weeks rather than seasons, which is the recurring cost conversation around this product. The same formula is sold in a 2 fl oz size for committed users; the 1 fl oz jar verified in this hub is the sensible first purchase.
Keep Researching
Every page in the Perricone MD edit.
- 01Perricone MD: the hubHub
- 02Best Perricone MD Products 2027: Three Signature Sciences, RankedBest of
- 03Building a Perricone MD Routine: The Cold Plasma Layering OrderGuide
- 04Perricone MD for the Look of Firmness: Neuropeptide and DMAE Lines by JobGuide
- 05Perricone MD Moisturizers Compared: Finishing, Balm and Gel CreamGuide
- 06Perricone MD Face Finishing & Firming Moisturizer Review: The Finish Is the ProductReview
- 07Perricone MD Vitamin C Ester Brightening Serum Review: The Gentle Ester, Judged FairlyReview
- 08Perricone MD Face Finishing & Firming vs Cold Plasma Plus+ Intensive Hydrating Complex: Finish or Cushion?Comparison
- 09Perricone MD Vitamin C Ester Brightening Serum vs CCC+ Ferulic Complex: Gentle Ester or 20 Percent Step-Up?Comparison
- 10Perricone MD Buying Guide: How to Build a Perricone Shelf by SystemBuying guide
- 11Perricone MD Care and Keeping: Layering, Retinol Ramps and Jar DisciplineCare
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