Focused Guide · The routine read as the brand publishes it: cleansing, then the Cold Plasma layer the house treats as its foundation step, then the targeted serum chosen by concern, then the moisturizer, with eye care slotted before the face cream.

Building a Perricone MD Routine: The Cold Plasma Layering Order

A Perricone MD routine assembled in the brand's own order: Nutritive Cleanser first, the Cold Plasma concentrate as the published first layer, targeted serums second, moisturizer last, with the eye cream placed where the brand puts it.

No. 1

The Selection

4 listings that answer this brief.

PMPerricone MDHigh Potency Classics Nutritive Cleanser 6 fl oz

No. 1

Perricone MD High Potency Classics Nutritive Cleanser 6 fl oz

Step One, Cleanse

The DMAE gel cleanser that starts the routine without stripping it

The routine starts here for a reason beyond tidiness: a DMAE and alpha lipoic acid gel that leaves skin softened means the concentrate that follows is not spent compensating for a stripping wash. Quarter sized amount, damp skin, morning and evening, as printed.

Suits

Normal to dry skin that wants the routine's first step to soften and condition while it cleanses, rather than leaving skin tight for the serums to fix

Skip if

You want a fragrance free, sulfate free cleanser on principle; the published ingredient list includes sodium laureth sulfate and parfum

Size: 6 fl oz (177 ml), also sold in a 2 fl oz size
Format: Gentle gel cleanser
Key ingredients: Alpha lipoic acid, DMAE, copper complex, alpha hydroxy acids
Use: Lather a quarter sized amount in hands, massage onto damp skin, rinse thoroughly with warm water, morning and evening
Range: High Potency Classics

View on AmazonPremium listing verified: Manufacturer recorded as AmazonUs/PEVEG for this product (UPC 651473710011, model 52430011) with the full manufacturer ingredient list published by the brand (DMAE, alpha lipoic acid, copper complex); the standalone Amazon ASIN was not confirmed in this verification pass, so none is recorded

Perricone MD Cold Plasma Plus+ Advanced Serum Concentrate black 30 ml jar with dark chrome lid

No. 2

Perricone MD Cold Plasma Plus+ Advanced Serum Concentrate 1 fl oz

Step Two, The Cold Plasma Layer

The house multitasker: copper tripeptide, vitamin C ester and DMAE in one jar

The brand positions Cold Plasma Plus+ as the layer everything else builds on, applied to face and neck after cleansing. In this routine it goes on first among the treatments, because its liquid crystal texture is the base the targeted serums were designed to sit over.

Suits

Anyone who wants one Perricone step to carry the routine: tone, texture, radiance and the look of firmness addressed by a single concentrate, morning and evening

Skip if

You prefer single job products whose effect you can isolate, or jar packaging puts you off a serum step

Size: 1 fl oz (30 ml) jar
Format: Serum concentrate in a jar, liquid crystal delivery system
Key ingredients: Copper Tripeptide-1, Vitamin C Ester, DMAE, omegas 3, 6 and 9, sodium hyaluronate
Use: Massage onto cleansed face and neck morning and evening, as the first treatment layer after cleansing
Range: Cold Plasma Plus+

View on AmazonPremium listing verified: Official Perricone MD brand content on the Amazon listing (From Perricone MD, with the manufacturer Cold Plasma Plus+ modules and the ASIN printed in the listing safety information); reused from the pilot peptide serums file

Perricone MD Vitamin C Ester Brightening Serum brown glass dropper bottle, 30 ml

No. 3

Perricone MD Vitamin C Ester Brightening Serum 1 fl oz

Step Three, The Targeted Serum

The gentle ester serum: vitamin C ester with squalane, made for daily brightening

One targeted serum, chosen by concern, is the discipline this guide teaches: the ester serum for brightness, the Growth Factor serum for the look of firmness, the Deep Crease Serum dotted onto creases. Pick one per session rather than stacking all three.

Suits

Skin that finds pure vitamin C too sharp: the ester form in a squalane base suits a calm, twice daily brightening step that never needs a rest day

Skip if

You want a printed vitamin C percentage and a fragrance free formula; neither is offered here

Size: 1 fl oz (30 ml) dropper bottle
Format: Dropper serum
Key ingredients: Vitamin C Ester, squalane, rosemary leaf extract, ferulic acid
Use: Apply to cleansed face morning and evening before moisturizer; the brand also suggests the eye and lip contours
Range: Vitamin C Ester

View on AmazonPremium listing verified: Manufacturer Perricone MD and model number 52260001 as printed in the Amazon listing product details, with manufacturer brand content for the Vitamin C Ester Brightening Serum on the listing; reused from the pilot vitamin C serums file

Perricone MD Face Finishing and Firming Moisturizer amber jar with black lid showing 59ml label

No. 4

Perricone MD High Potency Classics Face Finishing & Firming Moisturizer 2 fl oz

Step Four, Seal and Finish

The rose scented finishing cream: DMAE with a radiant finish built in

The moisturizer closes the routine and sets the finish: Face Finishing & Firming by day for its radiant surface, the Intensive Hydrating Complex at night when skin wants the balm. The eye cream goes on before this step, patted around the orbital bone.

Suits

Anyone whose moisturizer brief ends with the finish: skin that should look smooth, cushioned and radiant the moment the cream goes on, morning or evening

Skip if

You avoid fragrance entirely, since the velvety rose scent is a signature of this formula, or you want a matte finish

Size: 2 fl oz (59 ml) jar
Format: Rich cream moisturizer in a jar
Key ingredients: DMAE, vitamin E, kukui nut seed oil
Use: Massage onto cleansed face and neck in an upward motion, morning and evening, after serum
Range: High Potency Classics

View on AmazonPremium listing verified: Amazon.com listing presented From Perricone MD in the product summary, with manufacturer Perricone M.D. recorded against this ASIN in the listing details; reused from the pilot anti-aging creams file

No. 2

Questions, Answered

Does the Cold Plasma concentrate go before or after other serums?

Before, in the brand's own layering logic: it is the foundation treatment layer, applied to cleansed face and neck, with targeted serums following and moisturizer last. Its cream serum texture surprises people who expect a watery first step, but the published order is concentrate, serum, cream.

Can I run the full Perricone routine morning and evening?

Yes, with two adjustments. The Growth Factor serum contains encapsulated retinol, so introduce it in the evening first and build, whatever its day and night directions allow. And the morning routine ends with sunscreen over the moisturizer, which this brand's many brightening and retinoid formulas quietly assume.

Widen the lens in the full Best Perricone MD Products 2027: Three Signature Sciences, Ranked ranking, or return to the Perricone MD hub.

No. ·

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